Obstetric and Parental Psychiatric Variables as Potential Predictors of Autism Severity

Autor/inn/en	Wallace, Anna E.; Anderson, George M.; Dubrow, Robert
Titel	Obstetric and Parental Psychiatric Variables as Potential Predictors of Autism Severity
Quelle	In: Journal of Autism and Developmental Disorders, 38 (2008) 8, S.1542-1554 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-007-0536-4
Schlagwörter	Autism; Hypertension; Severity (of Disability); Depression (Psychology); Anxiety; Measures (Individuals); Behavior Patterns; Communication Skills; Scores; Prenatal Influences; Genetics; Psychiatry + Suchen Sie Ihr Suchwort? Autismus; Bluthochdruck; Hypertonie; Schweregrad; Angst; Messdaten; Kommunikationsstil; Pränataler Einfluss; Humangenetik; Psychiatrie
Abstract	Associations between obstetric and parental psychiatric variables and subjects' Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) domain scores were examined using linear mixed effects models. Data for the 228 families studied were provided by the Autism Genetic Resource Exchange. Hypertension (P = 0.002), preeclampsia (P = 0.021) and generalized edema (P = 0.011) were associated with higher ADI-R communication scores. Hypertension (P = 0.011), albuminuria (P = 0.039) and generalized edema (P = 0.009) were associated with higher ADI-R repetitive behaviors scores. Parent depression was associated with higher ADI-R repetitive behaviors scores (P = 0.005), and parent anxiety with lower ADOS social/communication composite scores (P = 0.025). The associations between hypertension-related obstetric conditions and autistic severity warrant further investigation and raise intriguing questions regarding potential causal and modifying factors in autism. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10